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Sisters of the Holy Spirit started mission activities in Tanzania opening its first center at Msolwa, on 8 th September 2008. This center comes under Ifakara Diocese. Here the province network with the Congregation of Missionaries of Compassion in the education and health ministries. Sisters teach in Compassion Secondary School (Shuleya Sekondari Compassion), Assumption Primary School (Shuleya Msingi Assumption) and Good Samaritan hospital. ( Samaria Mwema Hospitali).

Apart from teaching in the school this community runs a hostel Holy Spirit Hostel (Bweni la wasichana la Roho Mtakatifu) for both primary and secondary school. Community also involves in the pastoral activities of the parish.